Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy
نویسندگان
چکیده
منابع مشابه
Thyroid-associated Ophthalmopathy
Thyroid-associated ophthalmopathy is the most frequent extrathyroidal involvement of Graves' disease but it sometimes occurs in euthyroid or hypothyroid patients. Thyroid-associated ophthalmopathy is an autoimmune disorder, but its pathogenesis is not completely understood. Autoimmunity against putative antigens shared by the thyroid and the orbit plays a role in the pathogenesis of disease. Th...
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Background: Disasters have adverse impacts on different aspects of human life. Psychosocial Rehabilitation is one of the fields which is usually overshadowed and ignored by physical rehabilitation or its importance does not receive proper attention. This research attempts to study some lessons learned from Psychosocial Rehabilitation based on disaster experiences in Iran. M...
متن کاملBuilding the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy
The pathogenesis of orbital Graves' disease (GD), a process known as thyroid-associated ophthalmopathy (TAO), remains incompletely understood. The thyrotropin receptor (TSHR) represents the central autoantigen involved in GD and has been proposed as the thyroid antigen shared with the orbit that could explain the infiltration of immune cells into tissues surrounding the eye. Another cell surfac...
متن کاملthyroid-associated ophthalmopathy in iranian patients
we determined the frequency of clinical thyroid ophthalmopathy in iranian patients. this cross-sectional study was performed at the endocrinology institute of tehran university of medical sciences. all patients with documented thyroid disorders from september 2003 to july 2005 were recruited. eye examinations included evaluation of soft tissue changes, measurement of proptosis, lid width, lagop...
متن کاملThiazolidinedione precipitated thyroid associated ophthalmopathy.
Thyroid associated ophthalmopathy (TAO), a cardinal clinical pointer to diagnose Graves' disease (GD), is seen less frequently in our country than in the West, but can have sight threatening consequences. Smoking, diabetes, male gender, increasing age and radioactive iodine treatment for thyrotoxicosis are known precipitating factors for TAO. We report four cases of thiazolidinediones (TZD) pre...
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ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10020383